Approximately 14% to 23% of women develop depression during pregnancy and up to 16.7% develop depression within 3 months postdelivery.1 Perinatal depression (PND) is underdiagnosed and few women receive treatment.2 Untreated PND is associated with functional impairment and adverse health outcomes for mother and child, including obstetric and neonatal complications3 and a broad negative impact on child development.4 Maternal suicide is the leading cause of maternal death occurring within 1 year postpartum.5 Fortunately, safe and effective treatment options exist, including psychotherapy6 and antidepressants.7 However, an understanding of complementary health practices (CHPs) is important, because perinatal women may inquire about nonpharmacologic treatments. CHPs include a diverse range of practices that are developed outside of mainstream Western medicine. Most CHPs fall into two categories: natural products or mind and body practices. Natural products, including herbs, vitamins, minerals, and probiotics, are the most widely used CHP in the United States. Mind and body practices include techniques that are typically administered or taught by a practitioner. Physical activity interventions may also be conceptualized as a form of CHP. In general, women suffer from disorders, such as depression and anxiety, more often than men, for which CHPs are commonly pursued.8 Despite growing popularity of CHP, research is limited. In light of their increased use, we reviewed literature on CHPs for PND. We included specific approaches (ie, omega-3 fatty acids [O-3FA], folate, vitamin D, selenium, zinc, magnesium, B vitamins, physical activity, yoga) based on prevalence of use and availability of evidence from randomized controlled trials (RCT) in PND. In the absence of RCT evidence in PND, we included data from nonrandomized trials and studies addressing impact of these approaches on depressive symptoms within nonclinical populations.