مقاله انگلیسی رایگان در مورد ارتباط بهبود درمان در ADHD و وابستگی کوکائین – الزویر ۲۰۱۸

مقاله انگلیسی رایگان در مورد ارتباط بهبود درمان در ADHD و وابستگی کوکائین – الزویر ۲۰۱۸

 

مشخصات مقاله
ترجمه عنوان مقاله چگونه بهبود درمان در ADHD و وابستگی کوکائین به یکدیگر مرتبط است: تجزیه و تحلیل ثانویه
عنوان انگلیسی مقاله How treatment improvement in ADHD and cocaine dependence are related to one another: A secondary analysis
انتشار مقاله سال ۲۰۱۸
تعداد صفحات مقاله انگلیسی ۲۷ صفحه
هزینه دانلود مقاله انگلیسی رایگان میباشد.
پایگاه داده نشریه الزویر
نوع نگارش مقاله
مقاله پژوهشی (Research article)
مقاله بیس این مقاله بیس نمیباشد
نمایه (index) scopus – master journals – JCR – MedLine
نوع مقاله ISI
فرمت مقاله انگلیسی  PDF
ایمپکت فاکتور(IF)
۳٫۳۲۲ در سال ۲۰۱۷
شاخص H_index ۱۴۲ در سال ۲۰۱۸
شاخص SJR ۱٫۷۱۵ در سال ۲۰۱۸
رشته های مرتبط روانشناسی
گرایش های مرتبط روانشناسی بالینی
نوع ارائه مقاله
ژورنال
مجله / کنفرانس وابستگی به مواد مخدر و الکل – Drug and Alcohol Dependence
دانشگاه New York State Psychiatric Institute – Division of Substance Abuse – USA
کلمات کلیدی وابستگی به کوکائین؛ اختلال کم‌توجهی – بیش‌فعالی؛ معالجه؛ Adderall
کلمات کلیدی انگلیسی Cocaine Dependence; ADHD; Treatment; Adderall
شناسه دیجیتال – doi
https://doi.org/10.1016/j.drugalcdep.2018.03.043
کد محصول E9773
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فهرست مطالب مقاله:
Highlights
Abstract
Keywords
۱ Introduction
۲ Methods
۳ Results
۴ Discussion
۵ Conclusions
Contributors
Role of funding source
Conflict of interest
Acknowledgments
References

بخشی از متن مقاله:
Abstract

Background: Attention-deficit hyperactivity disorder (ADHD) is overrepresented among individuals seeking treatment for substance use disorders. We previously reported that treatment with extended release mixed amphetamine salts (MAS-XR) increased abstinence, compared to placebo, among patients with co-occurring ADHD and cocaine dependence. This secondary analysis investigates the temporal relationship between ADHD improvement and cocaine abstinence in the first six weeks of the trial. Methods: The study was a three-arm, randomized, double-blinded, placebo-controlled, 14-week trial comparing MAS-XR (60mg or 80mg daily) versus placebo among 126 participants with ADHD and cocaine dependence. An autoregressive cross-lagged structural equation model was fit and evaluated weekly ADHD improvement (defined as > 30% reduction in the Adult ADHD Investigator Symptom Rating Scale) and urine-confirmed abstinence over the first six weeks. Results: The proportion of patients with each of the possible overall patterns of response was: ADHD improves before cocaine abstinence: 24%; Cocaine abstinence occurs before ADHD improvement: 12%; ADHD improvement and abstinence occur during the same week: 6%; ADHD improves but abstinence never achieved: 34%; Abstinence achieved but ADHD never improves: 6%; Neither ADHD improvement nor abstinence: 18%. A significant cross-lagged association was found; subjects with ADHD improvement at week 2 had significantly higher odds of cocaine abstinence at week 3 (p = .014). Conclusion: When treating co-occurring ADHD and cocaine dependence with stimulant medication, abstinence is most likely preceded by improvement in ADHD, which tends to occur early with medication treatment. Other observed temporal patterns suggest the potential complexity of the relationship between ADHD and cocaine dependence.

Introduction

Attention deficit hyperactivity disorder, characterized by problems with executive deficits and impulsive behavior, is one of the most common childhood disorders and has prevalence rates up to 18% in children and adolescents (CDC, 2005). While some individuals have remission of their symptoms, most continue to have impairing symptoms into adulthood (Biederman et al., 2010; Sibley et al., 2016). Perhaps not surprisingly, ADHD is overrepresented among individuals with substance use disorders; a meta-analysis found an overall rate of 22% (van Emmerik-van Oortmerssen et al., 2012). Initially it was thought that individuals with cocaine use disorders would have elevated rates of ADHD compared to other substance use disorders because they would choose cocaine (or other stimulants) to self-medicate their underlying ADHD symptoms (even if the patient did not recognize it as such). Early work found elevated rates of ADHD among cocaine-dependent individuals (Levin et al., 1998a; Perez de Los Cobos et al., 2011), but the findings have been mixed regarding whether cocaine-dependent patients have higher rates of ADHD than other groups of substance dependent individuals (van de Glind et al., 2014; van Emmerik-van Oortmerssen et al., 2014). As argued by Khantzian et al. (1997) and Mariani et al. (2014), individuals with psychiatric disorders may use alcohol or drugs to lessen intolerable affect or other psychiatric symptoms, albeit often unsuccessfully. Further, individuals may initially use alcohol, nicotine or marijuana to mitigate these psychiatric symptoms, but a number of other factors, such as drug availability, positive subjective effects, the pharmacologic properties of the drug to induce tolerance or withdrawal, and the individual’s perception of harm may influence which drug or drugs an individual with ADHD initiates, consistently uses, and potentially develops a SUD from.

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