Today’s economic and social context is characterized by rapidly changing technologies and larger amounts of information that became difficult to manage for those unable to keep the pace with all the novelties. These facts affect businesses and generate the necessity of creating management systems aimed at improving every aspect of their activity. On the one hand, knowledge became the most important asset of an organization and knowledge management (KM) is of high importance to organizational profitability, efficiency and sustainability. All the top businesses developed KM systems that enable both effective use of knowledge and creation of new solutions to problems, as well as new knowledge (innovations). On the other hand, people are also a very important asset of an organization. From this perspective, their workplace safety and well-being is a key factor to efficiency. Ergonomics is aimed at developing solutions to workplace issues and activity interruptions generated by accidents, and at optimizing machines and work equipment. Human stands at the heart of ergonomics, as no system can operate without the presence of a human being. In order to achieve the best results of its activity, an organization should combine specific goals regarding knowledge, ergonomics, finance and economics, human resources and so on. The authors focus on the connection between KM and ergonomics, as these two domains have in common the human being and its capabilities. Without humans, knowledge is bare information stored on physical or virtual devices and ergonomics becomes a set of theories regarding design and engineering of machines and workplaces. Thus, the importance of KM in implementing ergonomics throughout organizational activity relies in the knowledge employees have and are able to use for performing efficient work and creating new knowledge to fructify across the organization.