مقاله انگلیسی رایگان در مورد پیوند کبد برای متاستازهای کبدی سرطان کولورکتال – هینداوی ۲۰۱۸

مقاله انگلیسی رایگان در مورد پیوند کبد برای متاستازهای کبدی سرطان کولورکتال – هینداوی ۲۰۱۸

 

مشخصات مقاله
انتشار مقاله سال ۲۰۱۸
تعداد صفحات مقاله انگلیسی ۸ صفحه
هزینه دانلود مقاله انگلیسی رایگان میباشد.
منتشر شده در نشریه هینداوی
نوع مقاله ISI
عنوان انگلیسی مقاله The New Era of Transplant Oncology: Liver Transplantation for Nonresectable Colorectal Cancer Liver Metastases
ترجمه عنوان مقاله پیوند کبد برای متاستازهای کبدی سرطان کولورکتال غیر قابل تنظیم
فرمت مقاله انگلیسی  PDF
رشته های مرتبط پزشکی
گرایش های مرتبط خون شناسی، گوارش و کبد
مجله مجله دانشکده پزشکی گوارش و کبد – Canadian Journal of Gastroenterology and Hepatology
دانشگاه University Health Network – University of Toronto – Canada
کد محصول E5937
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بخشی از متن مقاله:
۱٫ Background

Colorectal cancer (CRC) is the third most common diagnosed cancer and the fourth cause of cancer-related mortality worldwide [1]. In 2012, there were over 1.3 million new cases diagnosed and approximately 700,000 related deaths worldwide [1]. In Canada, CRC accounts for 13% of all cancers. In 2017, CRC has a projected incidence of 80 new cases per 100.000 people and 9,400 deaths related to this cancer [2]. The CRC incidence is higher in developed countries and its rising among people younger than 55 years old [3, 4]. Approximately 15–۲۵% of CRC patients will have distant metastases at the time of primary diagnosis, mainly to the liver [5]. Another 18%–۲۵% patients will develop distant metastases within 5 years from the first diagnosis [6]. Over the past decade, the survival of patients with metastatic CRC has improved substantially [7]. The 2-year overall survival (OS) for stage IV CRC increased from 21% in the 1990s to 35% in the 2010s [8]. These improved outcomes are mainly a consequence of improved efficacy of systemic therapies and an increase in the number of patients undergoing surgical treatment for CRC metastasis [7, 8]. Surgical resection combined with neoadjuvant and adjuvant chemotherapy is the standard curative treatment for colorectal liver metastases (CRLM) [9, 10]. Several studies have shown 5-year OS rates of 47%–۶۰% after hepatectomy for colorectal metastases [11–۱۳]. However, recurrence occurs in 40%–۷۵% of patients after liver resection [14–۱۶]. Of these recurrences, 50% occur in the liver [15–۱۷]. Repeated hepatectomy after hepatic recurrence has proven to be feasible and improves survival [18]. In contrast, the prognosis after recurrence of nonresectable CRC is dismal and the 5-year survival is less than 10% with palliative chemotherapy [19]. Liver resection is only feasible in 20–۴۰% of patients with CRLM [20]. A common issue that precludes liver resection in these patients is the insufficient liver remnant volume due to large burden of metastatic disease [21]. Given that liver resection in combination with chemotherapy is the best treatment option for these patients and only a minority are eligible for this treatment, liver transplantation (LT) is an attractive option. LT would offer an R0 resection with the widest possible margin.

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