مقاله انگلیسی رایگان در مورد تولید تخمیری پروتوپاناکسادیول – الزویر ۲۰۱۹

elsevier

 

مشخصات مقاله
ترجمه عنوان مقاله فرآیند زیستی یکپارچه برای تولید تخمیری پروتوپاناکسادیول توسط بازیافت زباله اتانول در طی فرآیند استخراج جریان پایین
عنوان انگلیسی مقاله An integrated bioprocess for fermentative production of protopanaxadiol by recycling ethanol waste during down-stream extraction process
انتشار مقاله سال ۲۰۱۹
تعداد صفحات مقاله انگلیسی ۸ صفحه
هزینه دانلود مقاله انگلیسی رایگان میباشد.
پایگاه داده نشریه الزویر
نوع نگارش مقاله
مقاله پژوهشی (Research Article)
مقاله بیس این مقاله بیس نمیباشد
نمایه (index) Scopus – Master Journals List – JCR
نوع مقاله ISI
فرمت مقاله انگلیسی  PDF
ایمپکت فاکتور(IF)
۷٫۰۹۶ در سال ۲۰۱۸
شاخص H_index ۱۵۰ در سال ۲۰۱۹
شاخص SJR ۱٫۶۲۰ در سال ۲۰۱۸
شناسه ISSN ۰۹۵۹-۶۵۲۶
شاخص Quartile (چارک) Q1 در سال ۲۰۱۸
مدل مفهومی ندارد
پرسشنامه ندارد
متغیر ندارد
رفرنس دارد
رشته های مرتبط زیست، شیمی
گرایش های مرتبط بیوشیمی، شیمی محیط زیست
نوع ارائه مقاله
ژورنال
مجله / کنفرانس مجله تولید پاک – Journal of Cleaner Production
دانشگاه  School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, PR China
کلمات کلیدی فرآیند زیستی یکپارچه، پروتوپاناکسادیول، تخمیر، بازیابی حلال آلی، ساکارومایسس سرویزیا
کلمات کلیدی انگلیسی Integrated bioprocess، Protopanaxadiol، Fermentation، Organic solvent recovery، Saccharomyces cerevisiae
شناسه دیجیتال – doi
https://doi.org/10.1016/j.jclepro.2019.06.190
کد محصول  E12691
وضعیت ترجمه مقاله  ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید.
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فهرست مطالب مقاله:
Abstract
۱٫ Introduction
۲٫ Materials and methods
۳٫ Results and discussion
۴٫ Conclusion
Conflicts of interest
Acknowledgements
Appendix A. Supplementary data
References

 

بخشی از متن مقاله:
Abstract

Solvent recovery and reutilization in bioprocess have great potential to reduce production cost and environmental harm. However, solvent recovery process is often energy-intensive and costly. In this study, we developed an integrated bioprocess for fermentative production of protopanaxadiol (PPD) from ethanol waste recycled in down-stream extraction process, achieving solvent recovery and reutilization in a cost-effective manner. In this integrated process, PPD isolation and purification were achieved by foam separation and resin chromatography, respectively; ethanol solution used as PPD extractant and chromatography eluent was recycled to be reused directly as yeast carbon source for PPD biosynthesis. Notably, in 3 batches of 5 L-fermentation productions, the recycled ethanol could compensate 81.3% of the ethanol used in fermentation. Since the lost PPD during chromatography elution was returned into the next-batch fermentation together with the recycled ethanol, the overall yield of 3- batch production (85.78%) was higher than the yield of single batch production (~75%). This study demonstrates a promising integrated bioprocess for triterpene compounds production from ethanol waste.

Introduction

Protopanaxadiol (PPD), a major bioactive component of Panax ginseng, is regarded as promising high-value pharmaceutical compound for tumor inhibition and depression treatment (Li et al., 2006; Popovich and Kitts, 2004; Hui et al., 2012b). Traditional PPD production relies on phytoextraction that is followed by hydrolysis or enzymolysis, and is a labor-intensive and highly polluting process. Synthetic biology technology provides an alternative method for producing PPD in engineered Saccharomyces cerevisiae (S. cerevisiae) (Xu et al., 2013). In recent years, considerable progress has been achieved for engineering yeast for high production of PPD (Dai et al., 2013; Zhao et al., 2016, 2017). However, the down-stream bioprocess of PPD isolation and purification has not yet been studied. The down-stream bioprocess is known to be relatively solvent intensive. It has been reported that for the production of 1 kg of commercially available active pharmaceutical ingredients a median value of 45 kg of material needs to be used, of which about 50% has been organic solvents (Henderson et al., 2007). Recovery of waste solvent through crystallization or membrane separation can offer significant benefits with regards to reduced storage and waste costs as well as increased compliance with environmental legislation. However, these recovery processes are highly energy-intensive and costly (Constable et al., 2007). Therefore, it is of great interest to find a new way to reutilize the wasted organic solvent to be recycled during down-stream bioprocess.

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