مقاله انگلیسی رایگان در مورد اثر BMI بر پارامترهای اسپرم و تغییرات متابولیت پلاسمای سمینال

مقاله سال 2017

The development of male infertility increased rapidly worldwide, which coinciding with the epidemic of obesity. However, the impact of weight abnormalities on sperm quality is still contestable. To assess the correlation between BMI and sperm parameters, we searched relevant articles in PubMed, Embase, Web of science, and Wanfang database published until June 2015 without language restriction. Otherwise, we also recruited some participants who attended fertility clinic as well as some general populations in this report. We performed a systematic review and meta-analysis about BMI and sperm parameters containing total sperm count, concentration, semen volume and sperm motility (overall and progressive). Metabolomic analysis of seminal plasma was performed to explore the mechanism from a new perspective. This study found standardized weighted mean differences (SMD) in sperm parameters (total sperm count, sperm concentration, and semen volume) of abnormal weight groups decreased to different degree compared to normal weight. Dose-response analysis found SMD of sperm count, sperm concentration and semen volume respectively fell 2.4%, 1.3% and 2.0% compared with normal weight for every 5-unit increase in BMI. Metabolomic analysis of seminal plasma showed that spermidine and spermine were likely to play a vital role in the spermatogenesis progress. This systematic review with meta-analysis has confirmed there was a relationship between BMI and sperm quality, suggesting obesity may be a detrimental factor of male infertility.

INTRODUCTION

The development of assisted reproductive technology and its exponential increase usage have reflected, to a certain extent, infertility has become a serious worldwide problem. Forty-eight point five million couples were infertile in 2010, and about 50% infertility is caused by male factors [1, 2]. Sperm quality and spermatogenesis is vital for male fertility. The stand or fall of these situations depends on multi-factors i.e. genetic, environmental, behavioral or dietary. As a growing social health problem, the effect of obesity is not to be sneezed at that costs to both the community and the individual since obesity may be related to cardiovascular disease, diabetes and cancers [3, 4]. Along with the prevalence of obesity in the world that the proportion of men who are overweightINTRODUCTION The development of assisted reproductive technology and its exponential increase usage have reflected, to a certain extent, infertility has become a serious worldwide problem. Forty-eight point five million couples were infertile in 2010, and about 50% infertility is caused by male factors [1, 2]. Sperm quality and spermatogenesis is vital for male fertility. The stand or fall of these situations depends on multi-factors i.e. genetic, environmental, behavioral or dietary. As a growing social health problem, the effect of obesity is not to be sneezed at that costs to both the community and the individual since obesity may be related to cardiovascular disease, diabetes and cancers [3, 4]. Along with the prevalence of obesity in the world that the proportion of men who are overweight.