| مشخصات مقاله | |
| ترجمه عنوان مقاله | فریتین سرم به عنوان یک نشانگر زیستی پیش بینی کننده در COVID-19. بررسی سیستماتیک، متاآنالیز و تحلیل متارگرسیون |
| عنوان انگلیسی مقاله | Serum ferritin as a predictive biomarker in COVID-19. A systematic review, meta-analysis and meta-regression analysis |
| انتشار | مقاله سال 2022 |
| تعداد صفحات مقاله انگلیسی | 10 صفحه |
| هزینه | دانلود مقاله انگلیسی رایگان میباشد. |
| پایگاه داده | نشریه الزویر |
| نوع نگارش مقاله |
مقاله پژوهشی (Research Article) |
| مقاله بیس | این مقاله بیس نمیباشد |
| نمایه (index) | Scopus – Master Journals List – JCR – Medline |
| نوع مقاله | ISI |
| فرمت مقاله انگلیسی | |
| ایمپکت فاکتور(IF) |
3.425 در سال 2020 |
| شاخص H_index | 83 در سال 2020 |
| شاخص SJR | 1.149 در سال 2020 |
| شناسه ISSN | 0883-9441 |
| شاخص Quartile (چارک) | Q2 در سال 2020 |
| فرضیه | ندارد |
| مدل مفهومی | ندارد |
| پرسشنامه | ندارد |
| متغیر | ندارد |
| رفرنس | دارد |
| رشته های مرتبط | پزشکی |
| گرایش های مرتبط | بیماری های عفونی و گرمسیری، بیماری های ریه |
| نوع ارائه مقاله |
ژورنال |
| مجله | مجله مراقبت های ویژه – Journal of Critical Care |
| دانشگاه | Department of Biochemistry, India |
| کلمات کلیدی | کووید -19، SARS-CoV-2 ،فریتین، هایپرفریتین، تشخیص، پیش بینی، نشانگر زیستی |
| کلمات کلیدی انگلیسی | COVID-19 – SARS-CoV2 – Ferritin – Hyperferritin – Diagnosis – Prognosis – Biomarker |
| شناسه دیجیتال – doi |
https://doi.org/10.1016/j.jcrc.2021.09.023 |
| کد محصول | E15823 |
| وضعیت ترجمه مقاله | ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید. |
| دانلود رایگان مقاله | دانلود رایگان مقاله انگلیسی |
| سفارش ترجمه این مقاله | سفارش ترجمه این مقاله |
| فهرست مطالب مقاله: |
| Abstract Keywords Abbreviation Introduction Material and method Result Discussion Conclusion Author contribution statement Funding Declaration of competing interest Acknowledgement Appendix A. Supplementary data References |
| بخشی از متن مقاله: |
| Abstract Available online xxxx Ferritin is a known inflammatory biomarker in COVID-19. However, many factors and co-morbidities can confound the level of serum ferritin. This current metaanalysis evaluates serum ferritin level in different severity levels in COVID-19. Studies evaluating serum ferritin level in different clinical contexts (COVID-19 vs. control, mild to moderate vs. severe to critical, non-survivor vs. survivor, organ involvement, ICU and mechanical ventilation requirement) were included (total 9 literature databases searched). Metaanalysis and metaregression was carried out using metaphor “R” package. Compared to control (COVID-19 negative), higher ferritin levels were found among the COVID-19 patients [SMD −0.889 (95% C.I. −1.201, −0.577), I2 = 85%]. Severe to critical COVID-19 patients showed higher ferritin levels compared to mild to moderate COVID-19 patients [SMD 0.882 (0.738, 1.026), I2 = 85%]. In meta-regression, high heterogeneity was observed could be attributed to difference in “mean age”, and “percentage of population with concomitant co-morbidities”. Non-survivors had higher serum ferritin level compared to survivors [SMD 0.992 (0.672, 1.172), I2 = 92.33%]. In meta-regression, high heterogeneity observed could be attributed to difference in “mean age” and “percentage of male sex”. Patients requiring ICU [SMD 0.674 (0.515 to 0.833), I2 = 80%] and mechanical ventilation [SMD 0.430 (0.258, 0.602), I 2 = 32%] had higher serum ferritin levels compared to those who didn’t. To conclude, serum ferritin level may serve as an important biomarker which can aid in COVID-19 management. However, presence of other co-morbid conditions/confounders warrants cautious interpretation. Introduction Human ferritin is composed of two subunits, namely ferritin heavy chain (FTH) and ferritin light chain (FTL) [1]. The FTH chain has ferroxidase activity and oxidizes Fe2+ to Fe3+. Fe3+ then moves towards the nucleation site on the FTL chain and thus by acting in a synchronizing way, iron oxidation and core formation is carried out [2]. The ferritin units assemble in the form of a sphere with a cage inside it, the outer and inner diameter of which is 12 and 8 nm respectively. This nano-cage (stable at pH range 3 to 9) separates iron in the core from the outside environment and thus protects the body from harmful effects of excess free iron [2]. One ferritin molecule can store upto 5000 iron atoms [2]. |