| مشخصات مقاله | |
| ترجمه عنوان مقاله | روابط بین نشانگرهای التهابی و وضعیت خطر خودکشی در افسردگی اساسی |
| عنوان انگلیسی مقاله | Relationships between inflammatory markers and suicide risk status in major depression |
| انتشار | مقاله سال 2021 |
| تعداد صفحات مقاله انگلیسی | 8 صفحه |
| هزینه | دانلود مقاله انگلیسی رایگان میباشد. |
| پایگاه داده | نشریه الزویر |
| نوع نگارش مقاله |
مقاله پژوهشی (Research Article) |
| مقاله بیس | این مقاله بیس میباشد |
| نمایه (index) | Scopus – Master Journals List – JCR |
| نوع مقاله | ISI |
| فرمت مقاله انگلیسی | |
| ایمپکت فاکتور(IF) |
4.791 در سال 2020 |
| شاخص H_index | 136 در سال 2020 |
| شاخص SJR | 1.875 در سال 2020 |
| شناسه ISSN | 0022-3956 |
| شاخص Quartile (چارک) | Q1 در سال 2020 |
| فرضیه | ندارد |
| مدل مفهومی | ندارد |
| پرسشنامه | ندارد |
| متغیر | دارد |
| رفرنس | دارد |
| رشته های مرتبط | روانشناسی، پزشکی |
| گرایش های مرتبط | روانشناسی بالینی، روانپزشکی |
| نوع ارائه مقاله |
ژورنال |
| مجله | مجله تحقیقات روانپزشکی – Journal of Psychiatric Research |
| دانشگاه | Department of Neurosciences and Mental Health, Psychiatry Department, Hospital de Santa Maria (CHULN), Lisbon, Portugal |
| کلمات کلیدی | التهاب، سیتوکینها، اسیدهای چرب اشباع نشده امگا 3 (PUFA) ، خودکشی کردن، افسردگی |
| کلمات کلیدی انگلیسی | Inflammation – Cytokines – Omega-3 polyunsaturated fatty acids (PUFA) – Suicide – Depression |
| شناسه دیجیتال – doi |
https://doi.org/10.1016/j.jpsychires.2020.12.029 |
| کد محصول | E15902 |
| وضعیت ترجمه مقاله | ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید. |
| دانلود رایگان مقاله | دانلود رایگان مقاله انگلیسی |
| سفارش ترجمه این مقاله | سفارش ترجمه این مقاله |
| فهرست مطالب مقاله: |
| Abstract Keywords Introduction Material and methods Results Discussion Conclusions Funding Author statement Declaration of competing interest Appendix A. Supplementary data Research Data References |
| بخشی از متن مقاله: |
| ABSTRACT Pro-inflammatory status has been implicated in depression and suicidal behaviors. Polyunsaturated fatty acids (PUFAs) and cytokines, two types of inflammatory biomarkers, have been associated with suicide, independent of depression severity. How these biomarkers relate to each other is less clear. We measured plasma phospholipid levels of arachidonic acid (AA%), docosahexaenoic acid (DHA%), and eicosapentaenoic acid (EPA%) as a percentage of total phospholipids, as well as serum interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), in 80 patients with major depressive disorder (MDD) and 24 healthy controls (HC). Individual PUFA and cytokine species were compared using ANOVA across four suicide risk-stratified groups: 1) highestrisk, recent (within 5 years) suicide attempters (n = 20); 2) high-risk, severe current suicidal ideators (having intent or plan) with no recent attempt history (n = 22); 3) low-risk, current non-ideators who were also lifetime non-attempters (n = 38); and 4) HC (n = 24). None of the participants were enrolled following an acute suicide attempt. Of biomarkers studied, only DHA% (p = 0.012) and IL-1β (p = 0.002) differed between groups. In posthoc testing, DHA% was lower in attempters than ideators (p = 0.018) or MDD non-ideators (trend level, p = 0.073). IL-1β was lowest in attempters, differentiating them from ideators (p = 0.009) and HC (p = 0.004). Recent suicide attempt, one of the most powerful predictors of suicide risk, was also most closely tied to inflammatory indices in this study. Low DHA% as an indicator of suicide risk is consistent with previous reports; however, lower IL-1β was unexpected and may relate to acuity/chronicity of inflammation. There is a need for prospective studies of immune status with respect to suicidal behaviors. Introduction According to the World Health Organization, 800,000 people die by suicide annually, with a rate of 10.7 per 100,000 individuals (WHO, 2020). Among psychiatric illnesses, depression is most commonly associated with suicide, accounting for 30% of cases (Bachmann, 2018). Despite efforts to develop new interventions, the suicide rate has consistently risen over the past two decades (Hedegaard et al., 2018). We also know little about the fundamental neurobiological causes of suicidal behaviors (van Heeringen and Mann, 2014). Many previously identified risk factors are not modifiable, such as prior attempt history, sex and age (Hawton et al., 2013) although depression severity is modifiable and effects a reduction in suicide risk (Gibbons et al., 2012). Thus, a paramount goal of suicide research is the identification of etiologic processes amenable to clinical intervention. Inflammation is one promising candidate for modification that may affect suicide risk, because pro-inflammatory states are associated with major depression and with suicidal behavior (reviewed in (Ganança et al., 2016)). Higher levels of pro-inflammatory (Lindqvist et al., 2009) cytokines are associated with suicidal ideation (Karlovi´c et al., 2012; Martinez et al., 2012; Monfrim et al., 2014; O’Donovan et al., 2013), with suicide attempt in both blood (Janelidze et al., 2011) and CSF (Lindqvist et al., 2009, 2011; Martinez et al., 2012), and with completed suicide in postmortem brain tissue (Hoyo-Becerra et al., 2013; Pandey et al., 2012; Tonelli et al., 2008) and in CSF of patients with previous violent suicide attempts and those who subsequently died by suicide (Lindqvist et al., 2011). |