مقاله انگلیسی رایگان در مورد کاربرد بیومدیکال هیدروژل کاراگینان آمیخته با نانوذرات اکسید روی – تیلور و فرانسیس 2022

Abstract

Introduction

Materials and methods

DPPH

Microbial studies

Result and discussion

Microbial studies

Conclusion

Acknowledgements

References

Abstract

     Nanotechnology involving biopolymers is comprehensively used in biomedical applications, planning sciences, and food development. The present work describes the synthesis, characterization, and application of carrageenan and zinc oxide nanoparticles (ZnONPs) based hydrogel. The synthesized hydrogels were subsequently characterized using FTIR, XRD, SEM, and TG-DTA. The swelling property, antioxidant activity, and whole blood clotting effectiveness of the Carrageenan hydrogel, and Carrageenan Hydrogels Impregnated with Zinc Oxide Nanoparticles were evaluated. The Carrageenan + ZnONPs (C/ZnONPs) hydrogels showed good antioxidant, and blood clotting activity than the pure carrageenan hydrogel. In addition, the stable C/ZnONPs hydrogels exhibit good antimicrobial activities against both Gram-negative and Gram-positive bacterial strains. Biofilm analysis showed that C/ZnONPs hydrogels have excellent anti-biofilm potential in both inhibition and disruption of preformed biofilm. The obtained results suggested that the carrageenan and Zinc oxide nanoparticles based hydrogel have promising biological applications.

Introduction

     Pathogenic microorganism resistance to frequently used antibiotic substances have become an important health concern in the 21st century. The development of microorganism resistance to antibiotics has significantly increased morbidity and mortality, longer hospitalization and increased health care costs.[1] Resistance is increasing against antibiotics, particularly to the first line, inexpensive, and broad-spectrum antibiotics, but also to the newly developed antibiotics; since the development of novel alternative is necessary.[2,3]

In the specific case of wound management there are several reports of the microorganism resistance to the drug used to manage wounds.[4] The role of microbial infections in the development of wound infections is well established, the life threatening nature of the wound infections has maximized its importance in human health. In addition, the cost of medication for wound management is also high.[5,6] Hence the exploration of new substance for the wound management is very important.

Conclusion

     The synthesized C/ZnONPs hydrogels was produced by a simple and efficient method, performing proper swelling capacity and much better mechanical properties. It exhibited better antioxidant, blood clotting activity and also possess excellent antibacterial and biofilm efficacy against B. subtilis, S. aureus, E. coli and K. pneumonia. The present study confirmed that C/ZnONPs hydrogel have multi-potential property. Thus, the present study suggests that this bio-reduction practice is a well suitable system for large-scale production. The blood clotting and biofilm efficacy were tested in this study only at the grassroot stage which needs to be addressed further.