مقاله انگلیسی رایگان در مورد دستورالعمل درمان تعدیل کننده بیماری ام اس – الزویر ۲۰۲۴
مشخصات مقاله | |
ترجمه عنوان مقاله | دستورالعمل درمان تعدیل کننده بیماری ام اس در امارات متحده عربی |
عنوان انگلیسی مقاله | Disease modifying treatment guidelines for multiple sclerosis in the United Arab Emirates |
نشریه | الزویر |
انتشار | مقاله سال ۲۰۲۴ |
تعداد صفحات مقاله انگلیسی | ۱۳ صفحه |
هزینه | دانلود مقاله انگلیسی رایگان میباشد. |
نوع نگارش مقاله |
مقاله پژوهشی (Research Article) |
مقاله بیس | این مقاله بیس نمیباشد |
نوع مقاله | ISI |
فرمت مقاله انگلیسی | |
فرضیه | ندارد |
مدل مفهومی | ندارد |
پرسشنامه | ندارد |
متغیر | ندارد |
رفرنس | دارد |
رشته های مرتبط | پزشکی |
گرایش های مرتبط | مغز و اعصاب |
نوع ارائه مقاله |
ژورنال |
مجله | ام اس و اختلالات مرتبط – Multiple Sclerosis and Related Disorders |
دانشگاه | Cleveland Clinic, Abu Dhabi, United Arab Emirates |
کلمات کلیدی | اسکلروز چندگانه (MS)، درمان تعدیل کننده بیماری، دستورالعمل ملی، امارات متحده عربی، خاورمیانه، خلیج، امارات متحده عربی (UAE) |
کلمات کلیدی انگلیسی | Multiple Sclerosis, Disease modifying treatment, National guideline, United Arab Emirates, Middle East, Gulf, UAE |
شناسه دیجیتال – doi |
https://doi.org/10.1016/j.msard.2024.105703 |
لینک سایت مرجع | https://www.msard-journal.com/article/S2211-0348(24)00280-3/fulltext |
کد محصول | e17858 |
وضعیت ترجمه مقاله | ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید. |
دانلود رایگان مقاله | دانلود رایگان مقاله انگلیسی |
سفارش ترجمه این مقاله | سفارش ترجمه این مقاله |
فهرست مطالب مقاله: |
Abstract ۱ Introduction ۲ Diagnosis of MS ۳ Defining RRMS severity and categories ۴ Treatment of acute attacks of MS ۵ Overview of DMT and consensus statements ۶ DMT recommendations ۷ Switching DMT ۸ Additional DMT in resource limited settings ۹ Autologous hematopoietic stem cell transplantation ۱۰ Discontinuing DMT ۱۱ Pediatric onset MS ۱۲ Pregnancy and DMT ۱۳ Breast feeding and DMT ۱۴ Conclusions Declaration of competing interest Acknowledgements References |
بخشی از متن مقاله: |
Abstract The newly constituted National Multiple Sclerosis (MS) Society (NMSS)of the United Arab Emirates (UAE), set up a scientific committee to create a MS disease modifying treatment (DMT) guideline for UAE. The committee considered several unique features of the MS community in UAE including large number of expatriate population, wide variations in health insurance coverage, physician and patient preferences for DMT. The overall goal of the treatment guideline is to facilitate the most appropriate DMT to the widest number of patients. To this end it has adapted recommendations from various health systems and regulatory authorities into a pragmatic amalgamation of best practices from across the world. Importantly where data is unavailable or controversial, a common sense approach is taken rather than leave physicians and patients in limbo. The committee classifies MS into subcategories and suggests appropriate treatment choices. It recommends treatment of RIS and CIS with poor prognostic factors. It largely equates the efficacy and safety of DMT with similar mechanisms of action or drug classes e.g. ocrelizumab is similar to rituximab. It allows early switching of treatment for unambiguous disease activity and those with progression independent of relapses. Autologous hematopoietic stem cell transplantation can be offered to patients who fail one high efficacy DMT. Pragmatic guidance on switching and stopping DMT, DMT choices in pregnancy, lactation and pediatric MS have been included. It is expected that these guidelines will be updated periodically as new data becomes available. Introduction The United Arab Emirates (UAE) is home to about 10 million people, of which one million are Emirati citizens. UAE is considered a country with medium prevalence for Multiple Sclerosis (MS). Estimates of prevalence are crude and range from 57/100,000 increasing to 64/100,000 when age-standardised (Inshasi & Thakre, 2011, Schiess et al., 2016, Mohammed, 2016). MS is more common in native Emirati people than in a mixed population of Emiratis and expatriates with the majority having relapsing MS (Schiess et al., 2016). All neurologists (not necessarily MS specialists) can manage MS. Primary care systems are not well established in UAE and patients self-refer to hospitals. Onward referrals to larger centres with expertise is uncommon, unless patients themselves chose to do so. Most MS Disease modifying treatments (DMT) are available in UAE. While UAE has a medical regulatory authority, its role has not yet extended into appraisals of individual medicines or cost effectiveness. Therefore, adoption of recommendations by the Food and Drug Administration(FDA) or European Medicines Agency (EMA) is the standard practice. There is presently no guideline for MS DMT in UAE. So, Neurologists use FDA, EMA approved drugs that are available in UAE as per their preferences and guided by the American Academy of Neurology (AAN), European Academy of Neurology (EAN) and Middle East North Africa Committee for Treatment and Research in MS (MENACTRIMS) guidelines (Yamout et al., 2024). This pragmatic approach combined with affordability (UAE per capita GDP is 44,315 USD compared to the EU 38,411 USD) (GDP comparision UAE and EU) has helped the quick introduction of new drugs in UAE once approved in North America or Europe. Conclusions MS is a complex chronic disease with high risk of long-term disability. In this broad and yet specific DMT guideline we have tried to put together pragmatic amalgamation of best practice from across the world that takes into account UAE’s unique situation and demography. The overall goal of the treatment guideline is to facilitate the most appropriate DMT to the widest number of patients and to facilitate emerging treatments earlier. Where data is unavailable or controversial, a common sense approach has been adopted rather than leave physicians and patients in limbo. It is expected that these guidelines will be updated periodically as new data becomes available. |