Reduction of growth rates below their optimum levels occurs under the environmental conditions referred to as abiotic stress (Cramer et al. 2011). Plants respond dynamically and reversibly to abiotic stress (Skirycz and Inzé ۲۰۱۰), because they must adapt to new conditions, and this response affects their growth and development (Santner and Estelle 2009). Abiotic stresses such as high salinity and drought always cause reductions in plant growth (Huang et al. 2012). Drought is an abiotic environmental factor and major stressor, which can decrease the plant’s development rate and its productivity (Agarwal et al. 2013). The nucleocytoplasmic receptors pyrabactin resistance (PYR), pyrabactin resistance-like (PYL), and regulatory component of abscisic acid (ABA) receptor (RCAR) bind to ABA phytohormone and inhibits type 2C protein phosphatases (PP2Cs) such as ABI1 and ABI2 (Park et al. 2009). Inactivation of PP2Cs leads to accumulation of active SNF1-related protein kinases/SnRK2s (Park et al. 2009; Umezawa et al. 2009). SnRK2s regulate ABA responsive transcription factors such as ABA-responsive element binding proteins (AREBs), leading to activation of ABA-responsive genes and ABA-related processes (Umezawa et al. 2009). Drought sensitive 1 (DRS1) is an ABA-dependent responsive gene required for ABA dependent signaling (Lee et al. 2010). ABA allows adaptation of plant cells to drought stress as a phytohormone and produced under drought stress and high salinity conditions.  ABA promotes tolerance to drought and salt stresses by controlling stomatal closure during daytime to avoid loss of water as well as activation of stress-related genes in plant cells (Nakashima et al. 2012). These stress-related genes can protect plant cells through the production of functional regulatory proteins and enzymes for cell signal transduction (Nakashima et al. 2012). The DRS1 gene is upregulated under water deficiency, and promotes tolerance to drought stress mediated by ABA. This gene encodes a WD-40 repeat 70 family protein involved in DDB1-CUL4-mediated protein degradation during the drought response, which was confirmed genetically using a genomic functional network modeling system. These findings suggest a significant association between DRS1 and ABA-mediated 73 responses to water deficiency in plants (Lee et al. 2010, 2011; Winkler et al. 2015).