مقاله انگلیسی رایگان در مورد اثرات کرم های خاکی بر سرنوشت ژن های مقاوم – الزویر 2018

The excessive use of antibiotics for human and veterinary applications results in widespread occurrences of antibiotic resistance bacteria (ARB) and antibiotic resistance genes (ARGs) in the natural environment. Waste water treatment plants (WWTP) receive sewages from different sources, making them possible the hotspots for ARB and ARGs (Guo et al., 2017; Rizzo et al., 2013). As the by-product of WWTP, high abundances of diverse ARB and ARGs have also been documented in dewatered sewage sludge (Li et al., 2013; Guo et al., 2017; Karkman et al., 2017). In contrast to the removal efficiency of ARGs in sewage treatment, their removal in sludge treatment seems less efficient (Yang et al., 2014). Moreover, the sewage sludge containing high organic matter and diverse microorganisms enables the ARGs to propagate and disseminate among bacterial species through horizontal gene transfer (HTG, Li et al., 2013; Guo et al., 2017). The HTG can help spreading the ARGs from commensal and 65 free-living species to pathogenic ones through three canonical modes of conjugation, transformation and transduction, making the ARGs difficult to be completely removed from the environment (Von Wintersdorff et al., 2016). Consequently, to control the ARB and ARGs in sludge, several studies have investigated their fates in different sludge treatment systems (Su et al. (2015; Yang et al., 2016; Zhang et al., 2016; Yang et al., 2014; Wu et al., 2016). Aerobic composting and anaerobic digestion are considered potential recycling methods for treating sludge. However, previous studies showed that the abundance and diversity of ARGs were significantly elevated during thermal composting for sludge (Su et al. (2015; Yang et al., 2016; Zhang et al., 2016). In addition, Su et al. (2015) found 156 unique ARGs and mobile genetic elements in composted sewage sludge.