مقاله انگلیسی رایگان در مورد تشنج در بارداری – الزویر 2018

Seizures are the most common major neurologic complication encountered in pregnancy with a prevalence of in the United States of 1.2%.1 Nearly one-half million women with epilepsy are of reproductive age and between 0.5% and 1.0% of all pregnancies occur among women with epilepsy.2,3 The etiology of seizures covers a wide range of diseases, vascular insults, infectious sequelae, malignant processes, metabolic derangements, toxic insults, primary central nervous system dysfunction, and more.4,5 In pregnancy, eclampsia represents a unique consideration among possible causes of seizure. Although epileptic seizures are the most common, it is crucial to accurately determine the underlying cause of seizures in pregnancy to provide appropriate therapy.

Epilepsy

Women with epilepsy who become pregnant are at a substantially increased risk of adverse outcomes, including preeclampsia, preterm labor, stillbirth, cesarean delivery, and a more than 10-fold increased risk of death.6 The majority of maternal deaths are related to poor seizure control. As such, achieving control of maternal epilepsy is the primary concern in the management of pregnant women with an underlying seizure disorder.3 This goal is complicated by the risk of potential congenital malformations owing to the use of antiepileptic therapy.