مقاله انگلیسی رایگان در مورد هیدروژل نانو کامپوزیت جدید برای پانسمان زخم – RSC 2015

Abstract

Graft copolymerization of diallyldimethylammonium chloride (DADMAC) vinyl monomer together with N,N‘- methylene-bis-acrylamide (MBA) crosslinking agent onto water soluble carboxymethyl cellulose CMC was carried out using ammonium persulfate (APS) initiator . The copolymerization resulted in hydrogels. Characterization and properties of these hydrogels were dependent on conditions affecting the copolymerization reaction and, in turn, control the pore size and porous structure of the hydrogels. Thus increasing the monomer concentration causes outstanding enhancement in the swelling ratio of the hydrogel provided that monomer is used at a concentration of 40% or more .The opposite holds true for initiator concentration; the swelling ratio of the hydrogel decreases significantly by increasing APS concentration from 0.05 to 0.25 mole/L. With respect to MBA crosslinker, maximum swelling ratio of 30 could be achieved with hydrogel prepared using MBA at concentration of 0.1 mole/L; hydrogel prepared in presence of MBA at 0.05 mole/L exhibits zero swelling ratio while hydrogel prepared using MBA at 0.3 mole/L displays swelling ratio of 10%, maximum swelling ratio for hydrogel could achieved at pH7 .Striking decrease in the swelling ratio of hydrogel is observed within pH range 2-6 as well as at pH 8. The hydrogel could also be successfully attached to modified cotton fabric, namely partially carboxymethylated cotton (PCMC) through ionic crosslinking The in situ formation of CuO nanoparticles inside the matrix of CMC-DADMAC hydrogel nanocomposites attached to cotton fabric was also investigated .The formation of CuO nanoparticles in the hydrogels was confirmed using X-ray diffraction and scanning electron microscopy studies. Furthermore, the functional performance of the novel CuO nanocomposite hydrogel as wound dressing was tested for antibacterial activities; the nanocomposite hydrogels demonstrated excellent antibacterial effect. The work was further extended to include synthesis and Page 1 of 28 RSC Advances 2 characterization of Ag/CMC-DADMAC hydrogel nanocomposites. The latter displays high antibacterial activity.