۱- Data

۲- Experimental design, materials and methods

References

Abstract

This data article provided additional data related to the research article entitled “Brain structural abnormalities in emotional regulation and sensory processing regions associated with anxious depression” Peng et al.,2019. Correlation analyses were conducted for clinical information (HAMD total, anxiety/somatization scores, HAMA total and illness duration) and identified regional gray matter volumes in all patients with anxious depression and non-anxious depression. More detailed correlation analysis was applied for each item of anxiety factor and reginal gray matter volumes to find which items were more associated with structural alterations in patients. Data showed that mean values of regional gray matter volumes in left postcentral gyrus (PCG) were positively associated with HAMD total and anxiety factor scores in anxious depression group. More detailed correlation analysis considering each item of anxiety factor revealed that, item 10 (psychic anxiety) and Item15 (hypochondriasis) were most significantly and positively associated with regional gray matter volumes in left PCG in anxious group. While HAMA scores and illness duration showed no significant correlation with any regional gray matter volume in both patient groups. Sample size matched groups were selected to explore possible replicability of imaging results. It revealed that different gray matter volumes in right inferior frontal gyrus were most robust findings among three groups. And anxious group had larger gray matter volumes in left PCG than non-anxious depression, despite of not survived after multiple comparisons corrections.

Data

This Data in Brief provided detailed results of correlation analyses between clinical characteristics (HAMD total, anxiety/somatization score, HAMA total and illness duration) and extracted mean values of regional gray matter volumes in whole anxious depression and non-anxious depression groups (Tables 1e5) [1]. The raw individual values of correlation analyses for each patient were listed in Tables 8e9 In addition, this data article presented imaging results for matched groups (Tables 6e7) [1].