مقاله انگلیسی رایگان در مورد خطر ابتلا به دمانس عروقی – الزویر ۲۰۲۰

مقاله انگلیسی رایگان در مورد خطر ابتلا به دمانس عروقی – الزویر ۲۰۲۰

 

مشخصات مقاله
ترجمه عنوان مقاله درمان بلوک‌کننده بتا و خطر ابتلا به دمانس عروقی: یک مطالعه آینده نگرانه مبتنی بر جمعیت
عنوان انگلیسی مقاله Beta-Blocker Therapy and Risk of Vascular Dementia: a Population-Based Prospective Study
انتشار مقاله سال ۲۰۲۰
تعداد صفحات مقاله انگلیسی ۲۶ صفحه
هزینه دانلود مقاله انگلیسی رایگان میباشد.
پایگاه داده نشریه الزویر
نوع نگارش مقاله
مقاله پژوهشی (Research Article)
مقاله بیس این مقاله بیس نمیباشد
نمایه (index) Scopus – Master Journals List – JCR
نوع مقاله ISI
فرمت مقاله انگلیسی  PDF
ایمپکت فاکتور(IF)
۳٫۳۰۹ در سال ۲۰۱۹
شاخص H_index ۸۶ در سال ۲۰۲۰
شاخص SJR ۱٫۲۷۷ در سال ۲۰۱۹
شناسه ISSN ۱۵۳۷-۱۸۹۱
شاخص Quartile (چارک) Q2 در سال ۲۰۱۹
مدل مفهومی ندارد
پرسشنامه ندارد
متغیر ندارد
رفرنس دارد
رشته های مرتبط پزشکی
گرایش های مرتبط مغز و اعصاب
نوع ارائه مقاله
ژورنال
مجله  فارماکولوژی عروقی – Vascular Pharmacology
دانشگاه  Department of Clinical Sciences, Lund University, Clinical Research Center, Malmö, Sweden
کلمات کلیدی دمانس عروقی، بلوک کننده بتا، آلزایمر، دمانس ترکیبی
کلمات کلیدی انگلیسی vascular dementia; beta-blocker; Alzheimer; mixed dementia
شناسه دیجیتال – doi
https://doi.org/10.1016/j.vph.2020.106649
کد محصول E14516
وضعیت ترجمه مقاله  ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید.
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فهرست مطالب مقاله:
Abstract
Graphical abstract
۱٫ Introduction
۲٫ Material and methods
۳٫ Results
۴٫ Discussion
۵٫ Strengths and limitations
۶٫ Conclusions
Ethical approval
Funding
Declaration of Competing Interest
Acknowledgments
References

بخشی از متن مقاله:
Abstract

There are a few studies that report cognitive impairment as a complication of treatment with beta- blockers. We aimed to evaluate the longitudinal association between use of betablockers, as a class, and incident risk of all-cause dementia, vascular dementia, Alzheimer and mixed dementia in the prospective population-based Malmö Preventive Project. We included 18,063 individuals (mean age 68.2, males 63.4%) followed up for 84,506 person-years. Dementia cases were retrieved from the Swedish National Patient Register and validated by review of medical records and neuroimaging data. We performed propensity score matching analysis, resulting in 3,720 matched pairs of beta-blocker users and non-users at baseline, and multivariable Cox proportional-hazards regression. Overall, 122 study participants (1.6%) were diagnosed with dementia during the follow-up. Beta-blocker therapy was independently associated with increased risk of developing vascular dementia, regardless of confounding factors (HR: 1.72, 95%CI 1.01-3.78; p=0.048). Conversely, treatment with beta-blockers was not associated with increased risk of all-cause, Alzheimer and mixed dementia (HR:1.15; 95%CI 0.80-1.66; p=0.44; HR:0.85; 95%CI 0.48–۱٫۵۴; P=0.59 and HR:1.35; 95%CI 0.56– ۳٫۲۷; p=0.50, respectively). We observed that use of beta-blockers, as a class, is associated with increased longitudinal risk of vascular dementia in the general elderly population, regardless of cardiovascular risk factors, prevalent or incident history of atrial fibrillation, stroke, coronary events and heart failure. Further studies are needed to confirm our findings in the general population and to explore the mechanisms underlying the relationship between use of beta- blockers and increased risk of vascular dementia.

Introduction

Dementia is a general term for neurodegeneration marked by the development of multiple cognitive deficits such as the ability to memorize, learn, perceive and process information 1 . Since the number of people affected by dementia is expected to increase rapidly 2 , the research to find different pathological mechanisms for prevention has been intensified 3 . Previous studies have revealed a possible relationship between blood pressure (BP) changes and the risk of developing dementia 4, 5. A decline in blood pressure between middle-and advanced age, and lower BP in advanced age have been disclosed as independent risk factors of incident dementia 6 . A theory has been proposed that blood pressure reduction causes a decline in cerebral perfusion, which has previously been emphasized as an important factor in the pathology in vascular dementia7 . Hence, antihypertensive treatment (AHT) which is commonly used among elderly individuals has been suggested to be implicated in dementia risk as the blood pressure lowering effect may reduce the cerebral perfusion 8 . A systematic review including fifteen randomized clinical trials studying the impact of different AHTs on cognition in older individuals without dementia reported an improvement in episodic memory in patients treated with angiotensin receptor blockers versus placebo or other types of antihypertensive drugs 9 . However, the knowledge is sparse on the adverse effects of AHT including potential harms such as orthostasis, fatigue, and depression, which can negatively impact daily functioning and quality of life 10.

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