مقاله انگلیسی رایگان در مورد نظارت درون رایانه ای گیاه پزشکی چینی – الزویر ۲۰۲۰

elsevier

 

مشخصات مقاله
ترجمه عنوان مقاله نظارت درون رایانه ای گیاه پزشکی چینی با پتانسیل برای جلوگیری مستقیم از کرونا ویروس جدید ۲۰۱۹
عنوان انگلیسی مقاله In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus
انتشار مقاله سال ۲۰۲۰
تعداد صفحات مقاله انگلیسی ۱۳ صفحه
هزینه دانلود مقاله انگلیسی رایگان میباشد.
پایگاه داده نشریه الزویر
نوع نگارش مقاله
مقاله پژوهشی (Research Article)
مقاله بیس این مقاله بیس نمیباشد
نمایه (index) Scopus – Master Journals List – MedLine
نوع مقاله ISI
فرمت مقاله انگلیسی  PDF
ایمپکت فاکتور(IF)
۱٫۹۵۴ در سال ۲۰۱۹
شاخص H_index ۲۴ در سال ۲۰۲۰
شاخص SJR ۰٫۵۰۲ در سال ۲۰۱۹
شناسه ISSN ۲۰۹۵-۴۹۶۴
شاخص Quartile (چارک) Q2 در سال ۲۰۱۹
مدل مفهومی ندارد
پرسشنامه ندارد
متغیر ندارد
رفرنس دارد
رشته های مرتبط پزشکی، کشاورزی
گرایش های مرتبط ویروس شناسی پزشکی، پزشکی داخلی، اپیدمیولوژی، بیماری های عفونی و گرمسیری، گیاه پزشکی
نوع ارائه مقاله
ژورنال
مجله  مجله داروی پیوسته – Journal of Integrative Medicine
دانشگاه  Secondary Military Medical University, Shanghai, China
کلمات کلیدی ۲۰۱۹-nCoV، کرونا ویروس ووهان، داروها، گیاه پزشکی چینی، ذات الریه، ترکیبات طبیعی، داکینگ مولکولی، فارماکولوژی شبکه ای
کلمات کلیدی انگلیسی ۲۰۱۹-nCoV; Wuhan coronavirus; Drugs, Chinese herbal; pneumonia; natural compounds; molecular docking; network pharmacology
شناسه دیجیتال – doi
https://doi.org/10.1016/j.joim.2020.02.005
کد محصول E14542
وضعیت ترجمه مقاله  ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید.
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فهرست مطالب مقاله:
Abstract

۱٫ Introduction

۲٫ Materials and methods

۳٫ Results

۴٫ Discussion

Acknowledgement

Appendix A. Supplementary data

References

بخشی از متن مقاله:

Abstract

Objective: In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronavirus that causes pneumonia

Methods: There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology Database. Compounds meeting both requirements were subjected to absorption, distribution, metabolism and excretion (ADME) evaluation to verify that oral administration would be effective. Next, a docking analysis was used to test whether the compound had the potential for direct 2019-nCoV interaction. In the second step we searched Chinese herbal databases to identify treatments containing the selected compounds. Plants containing 2 or more of the compounds identified in our screen were then checked against the catalogue for classic herbal usage. Finally, network pharmacology analysis was used to predict the general in vivo effects of each selected herb.

Results: Of the natural compounds screened, 13 that exist in traditional Chinese medicines were also found to have potential anti-2019-nCoV activity. Further, 125 Chinese herbs were found to contain 2 or more of these 13 compounds. Of these 125 herbs, 26 are classically catalogued as treating viral respiratory infections. Network pharmacology analysis predicted that the general in vivo roles of these 26 treatments were related to regulating viral infection, immune/inflammation reactions and hypoxia response.

Conclusion: Chinese herbal treatments classically used for treating viral respiratory infection might contain direct anti-2019-nCoV compounds

Introduction

Toward the end of December 2019, a novel coronavirus (2019-nCoV) with human-to-human transmission and severe human infection, originating in Wuhan, China, was identified [1]. This virus has affected many persons in China and spread to other countries in a very short time. On January 30, 2020, the Director-General of the World Health Organization declared that the outbreak of 2019-nCoV constitutes a public health emergency of international concern and issued temporary recommendations under the International Health Regulations [2]. According to the Daily Report of China National Health Commission, as of this writing on February 2, 2020, 14,488 cases, including 304 deaths, have been confirmed in China; 146 cases, including 1 death, have also been reported among 23 other countries. This pandemic is still ongoing, so it is urgent to find new preventive and therapeutic agents as soon as possible. In addition, commensurate with the risk, strong measures for early detection, isolation and treatment of cases, as well as minimization of transmission through social interaction must be implemented.

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