مشخصات مقاله | |
ترجمه عنوان مقاله | تغییر خطر ابتلا به سرطان و پیش سرطان دهان در جمعیت شمال هند توسط ژنوتیپ های پلی مورفیسم XPC و هاپلوتیپ ها |
عنوان انگلیسی مقاله | Alteration of the risk of oral pre-cancer and cancer in North Indian population by XPC polymorphism genotypes and haplotypes |
انتشار | مقاله سال ۲۰۱۹ |
تعداد صفحات مقاله انگلیسی | ۸ صفحه |
هزینه | دانلود مقاله انگلیسی رایگان میباشد. |
پایگاه داده | نشریه الزویر |
نوع نگارش مقاله |
مقاله پژوهشی (Research Article) |
مقاله بیس | این مقاله بیس نمیباشد |
نمایه (index) | Scopus – Master Journals List |
نوع مقاله | ISI |
فرمت مقاله انگلیسی | |
ایمپکت فاکتور(IF) |
۰٫۸۸۳ در سال ۲۰۱۸ |
شاخص H_index | ۱۴ در سال ۲۰۱۹ |
شاخص SJR | ۰٫۳۸۹ در سال ۲۰۱۸ |
شناسه ISSN | ۲۲۱۴-۵۴۰۰ |
شاخص Quartile (چارک) | Q4 در سال ۲۰۱۸ |
مدل مفهومی | ندارد |
پرسشنامه | ندارد |
متغیر | ندارد |
رفرنس | دارد |
رشته های مرتبط | پزشکی |
گرایش های مرتبط | خون و آنکولوژی، ایمنی شناسی پزشکی، پزشکی مولکولی، ژنتیک پزشکی |
نوع ارائه مقاله |
ژورنال |
مجله | متا ژن – Meta Gene |
دانشگاه | Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow campus, Lucknow 226028, India |
کلمات کلیدی | سرطان دهان، پیش سرطان دهان، XPC، پلی مورفیسم |
کلمات کلیدی انگلیسی | Oral cancer، Pre oral cancer، XPC، Polymorphism |
شناسه دیجیتال – doi |
https://doi.org/10.1016/j.mgene.2019.100583 |
کد محصول | E13025 |
وضعیت ترجمه مقاله | ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید. |
دانلود رایگان مقاله | دانلود رایگان مقاله انگلیسی |
سفارش ترجمه این مقاله | سفارش ترجمه این مقاله |
فهرست مطالب مقاله: |
Abstract
۱- Introduction ۲- Material and methods ۳- Results ۴- Discussion References |
بخشی از متن مقاله: |
Abstract Chewing and smoking of tobacco have been reported to cause DNA damage in oral mucosa which can be repaired by Xeroderma Pigmentosum Group C (XPC) protein. This study aimed to evaluate the association of XPC gene polymorphisms with the risk of oral diseases including oral pre cancer and cancer. In the present study we genotyped 302 patients with oral diseases and 300 healthy controls for XPC PAT (D > I), C > T and A > C polymorphisms with PCR-RFLP and PCR method. Haplotypes were constituted from different XPC genotypes with SNPstats programme. Our results show that individuals with D/I genotype for XPC D > I polymorphism were significantly protected from developing Oral submucous fibrosis (OSMF) and Leukoplakia (p = .۰۲۹ and 0.031 and respectively). Risk of oral cancer was also significantly lower with the I/I genotype of the same XPC polymorphism (p = .۰۴۸). However, once oral cancer is established, individual with I allele were at significantly increased risk for having high stage and metastatic tumor (p = .۰۱۱ and 0.03 respectively). Carrier of T allele for XPC C > T polymorphism were significantly protected from development of OSMF (p = .۰۰۴) but did not show any association with the development of other pre oral cancerous lesions or oral cancer. In contrast, CC genotype as well as C allele for XPC A > C polymorphism was significantly associated with increased risk of Lichenplanus (p = .۰۰۶ and 0.004 respectively). XPC C > T and A > C polymorphisms did not show any association with clinical parameters of oral cancer. Haplotype D/T/A and I/T/A showed protective association with development of oral disease (P-value = .۰۰۱ and 0.0001 respectively). In conclusion, results from the present study demonstrate association of XPC polymorphisms with oral pre cancer and cancer. Introduction Compared to the U.S. oral cancer development is high in India (Kekatpure and Kuriakose, 2010). In India, 20 per 100,000 people are affected by oral cancer which accounts for about 30% of all types of cancers. Invasive oral cancer is usually introduced by the presence of clinically known dysplasia of the oral mucosa or oral pre cancerous lesions. These oral pre cancers include, Lichen Planus, Leukoplakia, and Oral submucous fibrosis (OSMF). An oral pre cancerous lesion is defined as a benign, morphologically altered tissue that has a greater than normal risk of cancer transformation (Warnakulasuriya et al., 2007). Caffeine, tobacco, alcohol are known to be associated with a high number of cases of OSMF which are potentially malignant. Carcinogenic molecules from such substances are known to cause oxidative DNA damage to epithelial cells, and can be repaired by cell’s own DNA repair mechanisms (Frosina, 2000; Wood et al., 2001). However, faulty DNA repair systems, primarily occurring due to genetic polymorphisms may play a role in the development of oral pre cancer as well as oral cancer (Scully and Bagan, 2009). |