مشخصات مقاله | |
ترجمه عنوان مقاله | تغییرات ژنهای متابولیک و متابولیتها در سرطان |
عنوان انگلیسی مقاله | Alterations of metabolic genes and metabolites in cancer |
انتشار | مقاله سال 2012 |
تعداد صفحات مقاله انگلیسی | 21 صفحه |
هزینه | دانلود مقاله انگلیسی رایگان میباشد. |
پایگاه داده | نشریه الزویر |
نوع نگارش مقاله |
مقاله مروری (Review article) |
مقاله بیس | این مقاله بیس نمیباشد |
نمایه (index) | scopus – master journals – JCR |
نوع مقاله | ISI |
فرمت مقاله انگلیسی | |
ایمپکت فاکتور(IF) |
6.098 در سال 2017 |
شاخص H_index | 121 در سال 2019 |
شاخص SJR | 3.796 در سال 2017 |
شناسه ISSN | 1084-9521 |
شاخص Quartile (چارک) | Q1 در سال 2017 |
رشته های مرتبط | پزشکی |
گرایش های مرتبط | خون و انکولوژی – ژنتیک پزشکی |
نوع ارائه مقاله |
ژورنال |
مجله / کنفرانس | Seminars in Cell & Developmental Biology |
دانشگاه | Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA |
شناسه دیجیتال – doi |
https://doi.org/10.1016/j.semcdb.2012.01.013 |
کد محصول | E11808 |
وضعیت ترجمه مقاله | ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید. |
دانلود رایگان مقاله | دانلود رایگان مقاله انگلیسی |
سفارش ترجمه این مقاله | سفارش ترجمه این مقاله |
فهرست مطالب مقاله: |
Outline Abstract Keywords 1. Introduction 2. Classical cancer genes directly regulate metabolic enzymes 3. Eight metabolic genes encoding for four metabolic enzymes are mutated in human cancer 4. Mutations in FH, SDH, and IDH genes impair the function of α-KG and inhibit α-KG-dependent dioxygenases 5. Conclusion Acknowledgments References |
بخشی از متن مقاله: |
Abstract Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings—the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer—have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy. Introduction Otto Warburg observed more than 80 years ago that tumor cells have altered metabolic regulation; despite having an increased uptake of glucose, tumor cells produce much less ATP than expected from a complete tricarboxylic acid (TCA) cycle coupled to oxidative phosphorylation, and instead accumulate a significant amount of lactate [1–4]. Although the molecular mechanisms and significance of this shift to aerobic glycolysis in tumor cells, commonly known as the Warburg Effect, remain poorly understood, enhanced glucose uptake provides the basis for 18FDG-PET technology which has been widely used clinically for tumor detection by injecting patients with a radio-labeled glucose analog, 2(18F)- fluoro-2-deoxy-D-glucose (FDG), followed by imaging with positron emission tomography (PET). |