| مشخصات مقاله | |
| ترجمه عنوان مقاله | ویژگی های جنسی در علائم اضطراب و افسردگی در طول عمر و ارتباط آنها با تصویربرداری عصبی چندوجهی |
| عنوان انگلیسی مقاله | Sex-specificities in anxiety and depressive symptoms across the lifespan and their links with multimodal neuroimaging |
| انتشار | مقاله سال 2021 |
| تعداد صفحات مقاله انگلیسی | 10 صفحه |
| هزینه | دانلود مقاله انگلیسی رایگان میباشد. |
| پایگاه داده | نشریه الزویر |
| نوع نگارش مقاله |
مقاله پژوهشی (Research Article) |
| مقاله بیس | این مقاله بیس میباشد |
| نمایه (index) | Scopus – Master Journals List – JCR – Medline |
| نوع مقاله | ISI |
| فرمت مقاله انگلیسی | |
| ایمپکت فاکتور(IF) |
4.839 در سال 2020 |
| شاخص H_index | 188 در سال 2020 |
| شاخص SJR | 1.892 در سال 2020 |
| شناسه ISSN | 0165-0327 |
| شاخص Quartile (چارک) | Q1 در سال 2020 |
| فرضیه | ندارد |
| مدل مفهومی | ندارد |
| پرسشنامه | ندارد |
| متغیر | دارد |
| رفرنس | دارد |
| رشته های مرتبط | روانشناسی |
| گرایش های مرتبط | روانشناسی بالینی و روانشناسی عمومی |
| نوع ارائه مقاله |
ژورنال |
| مجله | مجله اختلالات عاطفی – Journal of Affective Disorders |
| دانشگاه | Department of Clinical Research, Caen Normandy Hospital (CHU) de Caen, France |
| کلمات کلیدی | سلامت روان، سالخورده، آتروفی، متابولیسم گلوکز، رسوب آمیلوئید |
| کلمات کلیدی انگلیسی | Mental health – Ageing – Atrophy – Glucose metabolism – Amyloid deposition |
| شناسه دیجیتال – doi |
https://doi.org/10.1016/j.jad.2021.10.004 |
| کد محصول | E15775 |
| وضعیت ترجمه مقاله | ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید. |
| دانلود رایگان مقاله | دانلود رایگان مقاله انگلیسی |
| سفارش ترجمه این مقاله | سفارش ترجمه این مقاله |
| فهرست مطالب مقاله: |
| Abstract Keywords Background Methods Results Discussion Conclusion Declarations of Competing Interest Acknowledgments Appendix. Supplementary materials References |
| بخشی از متن مقاله: |
| ABSTRACT Background: Anxiety and depressive symptoms are associated with impaired well-being, higher risk of developing psychoaffective disorders and are risk factors for Alzheimer’s disease (AD). To further understand their relevance and the mechanisms underlying their link with AD, our aims were to assess how anxiety and depressive symptoms changed with age and related to AD neuroimaging biomarkers across the adult lifespan, while also exploring sex specificities. Methods: 210 cognitively normal participants aged 19-86 years (101 men, 109 women) completed assessments of anxiety and depressive symptoms with the STAI-A and MADRS respectively, and neuroimaging measurements including structural MRI, FDG-PET and amyloid-PET. 167 of those were followed-up over 1.5–3 years. Multiple regressions were performed to assess the links between anxiety or depressive symptoms versus age, global cognition or each imaging modality, both cross-sectionally and longitudinally; and general linear models we used to test the interactive effect of sex on these associations. Results: Depressive symptoms decreased with age, while anxiety symptoms increased only among women. Higher anxiety symptoms were associated with lower grey matter (GM) volume and glucose metabolism, with an interaction of sex, this relationship being significant only in women. Longitudinally, only low baseline GM volume predicted an increase in anxiety symptoms with time. Limitations: Only 43% of participants reported depressive symptoms. Despite additional analyses, the low variability in the measure might have prevented us from detecting subtle changes. Conclusions: This study emphasizes the need to consider anxiety symptoms in assessments for dementia risk, particularly in women. Background Subclinical symptoms of anxiety and depression are frequently observed in older adults (Bryant et al., 2008; Forlani et al., 2014), and are associated with a high risk of developing anxiety and depressive disorders (Chambers et al., 2004; Cuijpers and Smit, 2004; Karsten et al., 2011). Elevated levels of anxiety and depression are associated with a worsening of the quality of life of seniors, fragility, sleep problems and cognitive disorders, or even with increased rates of mortality, morbidity and disability (Bryant et al., 2008; Cuijpers and Smit, 2004; Siegel and Mathews, 2015). Moreover, subthreshold anxiety and depressive symptoms were found to increase the risk of developing dementia (Harrington et al., 2015; Petkus et al., 2016; Singh-Manoux et al., 2017). Compared to individuals without symptoms of anxiety and depression, they were twice as likely to develop amnestic Mild Cognitive Impairment (MCI), a prodromal phase of Alzheimer’s dementia, over 3–6 years (Donovan et al., 2018). |