مقاله انگلیسی رایگان در مورد مطالعات همخوانی سراسر ژنوم درباره ارتباط هوش و سلامتی جسمانی – الزویر 2019

The associations between higher intelligence test scores from early life and later good health, fewer illnesses, and longer life are recent discoveries. Researchers are mapping the extent of these associations and trying to understanding them. Part of the intelligence-health association has genetic origins. Recent advances in molecular genetic technology and statistical analyses have revealed that: intelligence and many health outcomes are highly polygenic; and that modest but widespread genetic correlations exist between intelligence and health, illness and mortality. Causal accounts of intelligence-health associations are still poorly understood. The contribution of education and socio-economic status—both of which are partly genetic in origin—to the intelligence-health associations are being explored. Until recently, an article on DNA-variant commonalities between intelligence and health would have been science fiction. Thirty years ago, we did not know that intelligence test scores were a predictor of mortality. Fifteen years ago, there were no genome-wide association studies. It was less than five years ago that the first molecular genetic correlations were performed between intelligence and health outcomes. These former blanks have been filled in; however, the fast progress and accumulation of findings in the field of genetic cognitive epidemiology have raised more questions.

Intelligence, and health and death

Individual differences in intelligence, as tested by psychometric tests, are quite stable from later childhood through adulthood to older age [1,2]. The diverse cognitive test scores that are used to test mental capabilities form a multi-level hierarchy [1-3]; about 40% or more of the overall variance is captured by a general cognitive factor with which all tests are correlated, and smaller amounts of variance are found in more specific cognitive domains (reasoning, memory, speed, verbal, and so forth). Twin, family and adoption studies indicated that there was moderate to high heritability of general cognitive ability in adulthood (from about 50% to 70%), with a lower heritability in childhood [4]. It has long been known that intelligence is a predictor of educational attainments and occupational position and success [1]. Relatively recently, the “ultimate validity” of intelligence test scores was discovered, i.e. that higher intelligence significantly predicts later death. First, an Australian Vietnam Veterans study found that higher young-adult intelligence predicted lower risk of accidental deaths up to early middle age [5].