مقاله انگلیسی رایگان در مورد شيوع آنتي ژن اریتروسیت 1 سگ در 7414 سگ در ایتالیا – هینداوی 2017

 

مشخصات مقاله
انتشار مقاله سال 2017
تعداد صفحات مقاله انگلیسی 11 صفحه
هزینه دانلود مقاله انگلیسی رایگان میباشد.
منتشر شده در نشریه هینداوی
نوع مقاله ISI
عنوان انگلیسی مقاله Prevalence of Dog Erythrocyte Antigen 1 in 7,414 Dogs in Italy
ترجمه عنوان مقاله شيوع آنتي ژن اریتروسیت 1 سگ در 7414 سگ در ایتالیا
فرمت مقاله انگلیسی  PDF
رشته های مرتبط دامپزشکی
گرایش های مرتبط ایمنی شناسی دامپزشکی، علوم آزمایشگاهی دامپزشکی، جراحی دامپزشکی
مجله داروی دامپزشکی – Veterinary Medicine International
دانشگاه  Veterinary Transfusional Center (CTV) – Department of Veterinary Sciences
کد محصول E6325
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1. Introduction

Canine blood groups are recognized and have standardized terminology as Dog Erythrocyte Antigen (DEA). The DEA system includes seven well-known blood groups (DEA 1, 3, 4, 5, 6, 7, and 8) with over twenty antigen specificities [1–4]. Other nonstandardized antigens within DEA such as Dal [3, 5] and the recently described Kai 1 and 2 have been reported [6]. Canine blood groups comprise a two-allele system with a positive and negative type. The DEA 1 blood group system initially was described with 3 types, DEA 1.1, 1.2, and likely 1.3 [3, 7, 8]. Utilizing quantitative flow cytometry and an immunochromatographic technique with a monoclonal anti-DEA 1 alloantibody the continuum of DEA 1 negative to weakly (1+) up to strongly DEA 1 positive (4+) blood type was observed in contrast to the originally described DEA 1 system and with a significant correlation between these tests [9]. Recently, an autosomal dominant mode of inheritance of 4 alleles of DEA 1 with strong (4+) to weak (1+) reactivity was discovered. DEA 1 positive alleles are dominant over DEA 1 negative allele without any direct correlation with the historical DEA 1.2 positive subtype [10]. So now, it is accepted to speak about the DEA 1 group as a whole without any subtype [9, 10]. Natural occurring antibodies against DEA 1 antigen in dog’s erythrocytes have never been positively identified [11]. On the other hand, natural antibodies against DEA 3, 5, and 7 have been documented with a prevalence of 6%, 23%, and 45%, respectively [2]. However, although all canine blood group antigens can stimulate the formation of alloantibodies, DEA 1 seems to be the most immunogenic and also is considered the most clinically important. Alloantibodies will appear following the first transfusion in DEA 1 negative recipient dogs receiving positive DEA 1 red blood cells (RBCs) within 4–14 days [11–14]. Sensitization of the recipient and production of alloantibodies can result in a severe acute hemolytic transfusion reaction and even death if a second DEA 1 positive RBC transfusion is administered to the same patient [15–17]. The risk of alloantibody production and transfusion reactions against antigens other than DEA 1 is Hindawi Veterinary Medicine International Volume 2017, Article ID 5914629, 10 pages https://doi.org/10.1155/2017/5914629 2 Veterinary Medicine International not yet well defined [2] and there is no documented clinical evidence of a hemolytic reaction caused by DEA 1.2, 3, 5, and 7 in mismatched transfusions [18]. Blood typing to identify the presence of DEA 1 and the cross-match to establish full compatibility should be performed before each transfusion in order to reduce the risk of sensitization or immunological reaction between donor and recipient dogs [2, 19, 20].

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