مقاله انگلیسی رایگان در مورد بزرگ شدن آمیگدال در صرع لوب موقت – الزویر ۲۰۲۰

elsevier

 

مشخصات مقاله
ترجمه عنوان مقاله ضایعه طولانی مدت بزرگ شدن آمیگدال در صرع لوب موقت
عنوان انگلیسی مقاله Long term sequelae of amygdala enlargement in temporal lobe epilepsy
انتشار مقاله سال ۲۰۲۰
تعداد صفحات مقاله انگلیسی ۸ صفحه
هزینه دانلود مقاله انگلیسی رایگان میباشد.
پایگاه داده نشریه الزویر
نوع نگارش مقاله
مقاله پژوهشی (Research Article)
مقاله بیس این مقاله بیس نمیباشد
نمایه (index) Scopus – Master Journals List – JCR
نوع مقاله ISI
فرمت مقاله انگلیسی  PDF
ایمپکت فاکتور(IF)
۲٫۸۵۶ در سال ۲۰۱۸
شاخص H_index ۷۶ در سال ۲۰۱۹
شاخص SJR ۱٫۱۷۲ در سال ۲۰۱۸
شناسه ISSN ۱۰۵۹-۱۳۱۱
شاخص Quartile (چارک) Q2 در سال ۲۰۱۸
مدل مفهومی ندارد
پرسشنامه ندارد
متغیر ندارد
رفرنس دارد
رشته های مرتبط پزشکی
گرایش های مرتبط مغز و اعصاب
نوع ارائه مقاله
ژورنال
مجله / کنفرانس تشنج – seizures
دانشگاه  Calgary Comprehensive Epilepsy Program, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, AB, Canada
کلمات کلیدی آمیگدال، بزرگ شدن، صرع لوب موقت
کلمات کلیدی انگلیسی Amygdala، Enlargement، Temporal lobe epilepsy
شناسه دیجیتال – doi
https://doi.org/10.1016/j.seizure.2019.11.015
کد محصول  E14126
وضعیت ترجمه مقاله  ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید.
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فهرست مطالب مقاله:
Abstract
Abbreviations
۱٫ Introduction
۲٫ Methods
۳٫ Results
۴٫ Discussion
Funding
Declaration of Competing Interest
References

 

بخشی از متن مقاله:
Abstract

Purpose: Amygdala enlargement (AE) has been reported in drug resistant lesional and non-lesional temporal lobe epilepsy (TLE). Its contribution to development of intractability of epilepsy is at best uncertain. Our aim was to study the natural course of AE in a heterogenous group of TLE patients with follow-up imaging and clinical outcomes. Methods: A prospective observational study in patients with TLE with imaging features of AE recruited from epilepsy clinics between 1994 and 2018. Demographic data, details of epilepsy syndrome, outcomes and follow up neuroimaging were extracted. Results: Forty-two patients were recruited including 19 males (45 %). Mean age at onset of epilepsy was 30.6 years and mean duration of epilepsy was 19.9 years. On MRI, 33 patients had isolated unilateral AE and eleven had AE with hippocampal enlargement (HE). Twenty (48 %) underwent temporal resections with most common histopathology being amygdalar gliosis (40 %). Engel Class IA outcome at last follow up (mean, 10 years) was 60 %. Thirty-four patients had neuroimaging follow up of at least 1 year (mean, 5 years). AE resolved in 6, persisted in 25, evolved into bilateral HS in 1, bilateral mesial temporal atrophy in 1 and ipsilateral mesial temporal atrophy in 1. Resolution of AE was associated with better seizure free outcomes (p = 0.013). Conclusions: TLE with AE is associated with favourable prognosis yet not benign. Over 50 % were drug resistant and surgical outcomes were similar to mTLE. Resolution of AE on follow up neuroimaging was associated with better seizure free outcomes.

Introduction

Mesial temporal lobe epilepsy (mTLE) is major contributor to the group of drug resistant epilepsies and is one of the leading indications for epilepsy surgery, the most common pathology being hippocampal sclerosis (HS) [1]. There is a significant group of patients with mTLE that do not have any lesions on MRI, called “non-lesional” or “MRInegative [2]. These patients pose a challenge for treatment in terms of difficult presurgical work-up, frequently warranting intracranial EEG recordings. There is evidence that non-lesional patients fare worse in surgical outcomes in general as compared to lesional ones [3]. Interestingly, there is accumulating evidence that MRI-negative epilepsies are not necessarily non-lesional [4]. The amygdala, which is part of the limbic system, is known to be part of the epileptogenic network of patients with mTLE [5]. Intracranial EEG recordings have revealed interictal epileptiform discharges (IEDs) arising from the amygdala [6]. Structural abnormalities of the amygdala may be difficult to detect by conventional MR techniques [7], and thus may contribute to the so called non-lesional temporal lobe epilepsy (TLE-NL). Imaging studies of TLE-NL patients have identified amygdala enlargement (AE) as an increase in grey matter and amygdalar volume in 12 % of patients [8]. The same authors reported similar proportion (14 %) of AE in patients with mTLE and HS [9]. While the role of the amygdala is functionally defined and evidence of epileptogenicity in the amygdala exists, the significance of AE remains undefined.

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