مقاله انگلیسی رایگان در مورد تغییرات در شرایط دیابت نوع 2 در میان افراد مبتلا به دیابت نوع نوع 2 – الزویر 2020

1. Introduction

2. Methods

3. Results

4. Discussion

Acknowledgements

References

Abstract

Aims: To investigate levels and changes in diabetes distress over the course of the PRIORITY (Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In people with TYpe 2 diabetes and normoalbuminuria) randomised controlled trial of screening for diabetic kidney disease (DKD) risk among people with type 2 diabetes (T2D) at a specialist diabetes clinic in Denmark.

Methods: Of 436 trial participants with T2D, 216 were invited to complete the 17-item diabetes distress scale at the time of screening (T1, n = 180), immediately after receiving the screening results at 6–8 weeks (T2, n = 169), and at 12 months follow up (T3, n = 107). Linear mixed models were used to explore changes in diabetes distress.

Results: No significant changes in diabetes distress were observed between the time of screening, receiving results, and at 12 months. Changes in diabetes distress were not influenced by diabetes empowerment, sense of coherence, or perceived support for diabetes self-management.

Conclusions: In contrast to previous studies demonstrating that screening programmes can have negative psychological consequences, our findings indicate that participating in this screening programme for DKD does not influence emotional burden or physician-related distress among people with T2D

Introduction

People with diabetes have increased mortality and morbidity. Diabetes-related complications include macrovascular complications such as cardiovascular disease and microvascular complications such as nephropathy, neuropathy, and retinopathy, which are associated with lower quality of life and high healthcare costs.1 Identification and appropriate treatment of people with type 2 diabetes mellitus (T2D) at high risk of developing diabetes-related complications are core disease management activities.

Identification of people at risk of diabetic kidney disease (DKD) typically occurs through screening for albuminuria and kidney function at routine visits when people are still without symptoms of DKD.3 However, the urinary proteomics classifier CKD273 has been suggested as an improved marker for early identification of people at high risk of DKD compared to traditional methods.4 The clinical multicentre intervention trial PRIORITY (Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In people with TYpe 2 diabetes and normoalbuminuria) used this method to screen for future risk of DKD in people with T2D and normal kidney function.