مقاله انگلیسی رایگان در مورد دستورالعمل های JAID / JSC برای مدیریت بیماری های عفونی – الزویر 2021

1.Introduction

2.Sepsis

3.Catheter-related bloodstream infection

4.Supplementary data

References

1. Introduction

Sepsis is one of the most serious conditions among all infectious diseases. To establish a sepsis treatment system as the basis of bacterial infection treatment, knowledge regarding infectious disease medicine/chemotherapeutics must be collected. Due to the recent appearance of various antimicrobial-drug-resistant bacteria, it is necessary to flexibly switch strategies to treat bacterial infection. This is not exceptional in the field of sepsis. It is also necessary to manage such infection, considering the involvement of antimicrobial-drug-resistant bacteria, including MRSA(methicillin resistant Staphylococcus aureus) and ESBL(extended spectrum β-lactamase)-producing bacteria. Antimicrobial-drug-resistant bacteria have been routinely detected in patients not only with nosocomial but also with community-acquired infection.

Sepsis is defined as a severe condition derived from a primary infection site. On the other hand, we often encounter patients with narrow-sense blood stream infection caused by intravascularly inserted catheters in clinical practice. Although there is a dissociation as a condition to be described in the “Sepsis” section, it was included in this section for convenience. In patients with sepsis, as a rule, a primary infected focus should be investigated, and treatment must be performed in accordance with the site of infection and condition. However, in the present guidelines, antimicrobial chemotherapy as empiric therapy is described, focusing on initial treatment with antimicrobial drugs for sepsis at a time point when a primary focus is unclear or inaccurate. In the “Catheter-related bloodstream infection” section, definitive therapy after the identification of causative bacteria is concretely described.