مقاله انگلیسی رایگان در مورد اثربخشی ۳ تزریق هفتگی در مقایسه با ۵ تزریق هفتگی هیالورونات سدیم داخل مفصلی- PMR 2017

Abstract

Objective: To investigate whether the number of hyaluronic acid (HA) injections in a sodium hyaluronate (Hyalgan) course of therapy alters effectiveness in reducing knee osteoarthritis (OA) pain. Data Sources: Electronic databases, including PubMed and Embase, were searched from January 1980 until November 2015.

Study Selection: We included clinical studies that evaluated the effectiveness of a course of 3 or 5 weekly intra-articular injections of Hyalgan to treat knee OA pain. We also included clinical studies evaluating the effectiveness of a 3-week course of other Food and Drug Administrationeapproved HA treatments of knee OA pain. Twenty-four studies were identified, comprising 2168 study participants in 30 treated cohorts.

Data Extraction: We determined effect sizes for selected studies by extracting knee OA pain scores before and after HA or control treatments. Meta-regressions were implemented to determine whether the number of weekly injections in a course of Hyalgan therapy modified outcomes.

Hyaluronic acid (HA) is a glycosaminoglycan found within the extracellular matrix of various soft connective tissues and epithelial and neural tissues. This polysaccharide is a natural biopolymer consisting of repeating units of the disaccharide N-acetylglucosamine and sodium glucuronate. The rheologic properties of HA, transitioning between viscous and elastic behavior, play an important role in its ability to protect articular joints from the shear forces of rapid motion. An essential component of synovial fluid in the knee joint, HA enables the fluid to act as a lubricant and shock absorber. Osteoarthritis (OA) is characterized by both a loss of articular cartilage and a reduction in the viscoelastic properties of synovial