In the fast-growing Internet of Things (IoT), applications from personal devices to industrial instruments and sensors connect wirelessly to the Internet. Considering that a broad diversity of use cases in different environments with specific requirements can be developed, it is clear that no single wireless standard can abundantly predominate. With many standards available on the market, spread over various frequency bands and employing diverse communication protocols, the choice of the best wireless connectivity technology for an IoT application can be quite challenging. The first issues to be evaluated are the frequency bands and global regulations. In fact, in most regions, the available spectrum assignment is subdued to a licensing scheme, which implies that users have to obtain a license from the local regulator to transmit signals in a selected frequency channel. On the contrary, several frequency bands have been designated for Industrial, Scientific, and Medical (ISM) applications. These bands are unlicensed and differ slightly from country to country. In recent years, the popular ISM bands have involved 433 MHz, 868 MHz, 915 MHz, 2.4 GHz, and 5 GHz. Nevertheless, as a standard rule, it is well-known that higher-frequency bands offer a broader bandwidth and hence make broader bandwidth and more channels available. As a consequence, they can serve more extended networks and handle a higher data throughput. Contrariwise, lower-frequency radio waves propagate better than higher-frequency ones and can thus achieve a longer range, especially inside buildings. Another characteristic to be analyzed is the communication protocol. In fact, for several years, numerous protocols have been developed following a layered network implementation. This choice, on the one hand, includes complexity and needs more code and memory. Furthermore, it also implies data overhead because each layer expects further framing and control messages. Nonetheless, on the other hand, layered networks facilitate more flexibility and scale. For instance, it is useful to note that a simple network scheme, with no or limited layering, is represented by a proprietary application protocol, operating directly over the physical layer equipped with a simple radio transceiver. It is clear that this type of solution can be pretty efficient, but it can be used only in simple, single-function networks.