مقاله انگلیسی رایگان در مورد رویکرد فارماکولوژی شبکه برای کشف مکانیزم Hedyotis diffusa Willd – هینداوی ۲۰۱۸

مقاله انگلیسی رایگان در مورد رویکرد فارماکولوژی شبکه برای کشف مکانیزم Hedyotis diffusa Willd – هینداوی ۲۰۱۸

 

مشخصات مقاله
انتشار مقاله سال ۲۰۱۸
تعداد صفحات مقاله انگلیسی ۱۳ صفحه
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منتشر شده در نشریه هینداوی
نوع مقاله ISI
عنوان انگلیسی مقاله A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer
ترجمه عنوان مقاله رویکرد فارماکولوژی شبکه برای کشف مکانیزم Hedyotis diffusa Willd. در سرطان کولورکتال
فرمت مقاله انگلیسی  PDF
رشته های مرتبط پزشکی و داروسازی
گرایش های مرتبط فارماکولوژی
مجله پزشکی تکمیلی و جایگزین مبتنی بر شواهد – Evidence-Based Complementary and Alternative Medicine
دانشگاه Beijing University of Chinese Medicine – China
کد محصول E5946
وضعیت ترجمه مقاله  ترجمه آماده این مقاله موجود نمیباشد. میتوانید از طریق دکمه پایین سفارش دهید.
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بخشی از متن مقاله:
۱٫ Introduction

Colorectal cancer (CRC) is a multifactorial disease concerning environmental, lifestyle, genetic, or other risk factors [1], and it has posed a formidable potential threat to public health owing to its high morbidity and mortality [2]. Treatment strategies for CRC include surgery, chemotherapy, radiotherapy, targeted therapies, and immunotherapy [3–۵]. The therapies for CRC have been well developed in recent decades [6]; nevertheless, its mortality remains relatively high as a result of frequent recurrence and metastasis [4]. The main therapeutic option for CRC is chemotherapy, and appropriate chemotherapy approaches effectively prolong the life expectancy and improve the performance status of patients with CRC [7, 8]. However, the application of chemotherapy for CRC is largely limited by its fearful side effects and drug resistance [4]. Take FOLFOX (oxaliplatin, 5-fluorouracil, and leucovorin) as an example. FOLFOX is one of the most prevalent chemotherapy regimens and is also a standard first-line treatment strategy for CRC [9, 10]. Even so, when patients with CRC are treated with FOLFOX, a variety of side effects often occur, such as bone marrow suppression, gastrointestinal reaction, and abnormal liver function [11]. Given this, more effective and less toxic therapies are desperately needed for treating CRC [12]. As a well renowned traditional Chinese folk medicine, Hedyotis diffusa Willd. (HDW) belongs to the Rubiaceae family and is a natural herbal remedy usually found in the orient and tropical Asia in countries such as China, Japan, and Indonesia [13, 14]. In terms of traditional Chinese medicine (TCM) theory, HDW possesses heat-clearing, detoxification, promotion of blood circulation, and removal of blood stasis effects [15]. HDW has long been extensively utilized in several Chinese medicine formulae to clinically treat inflammatory and infectious diseases like sore throat, bronchitis, hepatitis, urethritis, and appendicitis [16–۲۰]. Moreover, HDW has also been used as an adjuvant therapy for the treatment of certain malignancies, including colorectal, liver, stomach, lung, and breast cancers, with relatively fewer and milder side effects [18, 21–۳۰].

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