مقاله انگلیسی رایگان در مورد درمان بازسازی بافت مبتنی بر سلولهای بنیادی مزانشیمی – الزویر 2020

1- Introduction

2- Development of periodontal tissue

3- Periodontal tissue regeneration with somatic NCCs and MSCs

4- Tissue engineering for periodontal tissue regeneration

5- Periodontal tissue regeneration using pluripotent stem cells

6- Discussion

References

Abstract

Periodontitis is commonly observed and is an important concern in dental health. It is characterized by a multifactorial etiology, including imbalance of oral microbiota, mechanical stress, and systemic diseases such as diabetes mellitus. The current standard treatments for periodontitis include elimination of the microbial pathogen and application of biomaterials for treating bone defects. However, the periodontal tissue regeneration via a process consistent with the natural tissue formation process has not yet been achieved. Developmental biology studies state that periodontal tissue is composed of neural crest-derived ectomesenchyme. To elucidate the process of periodontal regeneration, it is essential to understand the developmental background and intercellular cross-talk. Several recent studies have reported the efficacy of transplantation of mesenchymal stem cells for periodontal tissue regeneration. In this review, we discuss the basic knowledge of periodontal tissue regeneration using mesenchymal stem cells and highlight the potential of stem cell-based periodontal regenerative medicine.

Introduction

Periodontal tissues include soft tissues such as gingiva and periodontal ligaments (PDLs) and hard tissues such as the alveolar bones. Periodontitis is usually defined as bone resorption and periodontal tissue destruction due to acute (sometimes aggressive) or chronic inflammation. And periodontitis is very important concerns not only in dental health but also systemic health. The primary treatments for periodontal tissue inflammation include scaling and root planing and periodontal surgery for periodontal tissue reconstruction. Periodontal tissue regeneration using guided tissue regeneration and enamel matrix derivatives are being used for 2e3-wall alveolar bone defects [1,2]. These methods depend on mesenchymal stem cells (MSCs) residing in the periodontal tissues, space provision for the differentiation of MSCs, and the availability of growth factors.