مقاله انگلیسی رایگان در مورد عواقب احتمالی قلبی ترومبوسیتوپنی و ترومبوسیتوز – الزویر 2018

This report illustrates the heart in three patients with cardiac hemorrhages associated with extreme thrombocytopenia, and the hearts in three patients with rocks speculated to result at least in part from organization of thrombi possibly related to thrombocytosis in one or more cardiac chambers.

Introduction

Nearly 50 years ago an article on morphologic features of the heart in acute leukemia described numerous hemorrhagic lesions (extravasated erythrocytes) in the epicardium, myocardium, and endocardium, and the authors suggested that their cause was severe thrombocytopenia [1]. In subsequent years, numerous other examples of the hemorrhagic lesions have been observed in the heart and in nearly all non-traumatic cases the platelet counts were found to be extremely low (usually about 10,000 per uL). Also, subsequently we encountered several cases of calcified masses in one or more chambers in the heart [2, 3, 4]. The cause of the “rocks in the heart” was not determined but organization of platelet thrombi, as a consequence of thrombocytosis, would appear to be an explanation worthy of serious consideration. This report illustrates a few cases studied at necropsy with severe thrombocytopenia, and a few cases of “rocks in the heart” that may have formed by collections, at least initially, of clumps of platelets (Figures 1 and 2).